CD19 Mouse Monoclonal Antibody [Clone ID: 4G7]
CAT#: AM26006PU-N
CD19 mouse monoclonal antibody, clone 4G7, Purified
Conjugation: APC Biotin FITC PE PerCP
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CNY 3,140.00
Specifications
Product Data | |
Clone Name | 4G7 |
Applications | FC, IF |
Recommend Dilution | Flow Cytometry: 1 μg/ml. Immunocytochemistry. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human CCL (chronic lymphocytic leukemia) cells |
Specificity | This antibody recognizes CD19 (B4), a 95 kDa type I transmembrane glycoprotein of immunoglobulin superfamily, expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells. |
Formulation | PBS, pH~7.4 with 15 mM Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) |
Concentration | lot specific |
Purification | Protein-A affinity chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | CD19 molecule |
Database Link | |
Background | CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity. |
Synonyms | Leu-12, B-cell marker |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | B cell receptor signaling pathway, Hematopoietic cell lineage, Primary immunodeficiency |
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