CD62P (SELP) Mouse Monoclonal Antibody [Clone ID: AK4]
CAT#: AM26020LE-N
CD62P (SELP) mouse monoclonal antibody, clone AK4, Low Endotoxin
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CNY 3,140.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | AK4 |
Reactivity | Human, Primate |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human platelets |
Specificity | This antibody recognizes CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes; it is relocated to the plasma membrane upon activation. |
Formulation | Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized State: Low Endotoxin State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein-A affinity chromatography; > 95% pure (by SDS-PAGE) |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Gene Name | selectin P |
Database Link | |
Background | CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster. |
Synonyms | SELP, GMRP, GRMP, PADGEM, GMP-140, LECAM3 |
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