CD73 (NT5E) Mouse Monoclonal Antibody [Clone ID: AD2]

Specifications

Product Data
Clone Name	AD2
Applications	FC
Recommend Dilution	Flow Cytometry analysis of Human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody AD2 recognizes CD73, a 70 kDa GPI-anchored 5´-nucleotidase expressed predominantly on T and B cell subsets, follicular dendritic cells and endothelial cells.
Formulation	PBS Label: FITC State: Liquid purified Ig fraction Preservative: 15 mM Sodium Azide Label: Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use.
Conjugation	FITC
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE! This products is photosensitive and should be protected from light.
Gene Name	5'-nucleotidase ecto
Database Link	Entrez Gene 4907 Human UniProt ID P21589
Background	CD73 (ecto-5´-nucleotidase) is a 70 kDa glycoprotein anchored to the extracellular leaflet of the plasma membrane by GPI. This ecto-enzyme catalyzes dephosphorylation of AMP to adenosine. CD73 is expressed in various types of cells, such as epithelial, muscle, and endothelial cells, neutrophils, lymphocytes and fibroblasts. Inflammatory mediators support CD73 expression and its enzymatic activity, leading to the release of adenosine, which modulates inflammation through adenosine receptors. CD73 is expressed in a variety of lymphomas and leukemias, including ALL and CLL, whereas immunodeficient patients usually express low levels of this protein.
Synonyms	NT5, NTE, NT5E
Reference Data

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