PMP22 (N-term) Mouse Monoclonal Antibody [Clone ID: CF1]

Specifications

Product Data
Clone Name	CF1
Applications	ELISA, IHC, WB
Recommend Dilution	Immunoassay. Western blot: The typical starting working dilution is 1:50. Immunohistochemistry on paraffin sections.
Reactivity	Human, Monkey, Rhesus Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Peptide corresponding to amino acids 121-133 in the second extracellular domain of human PMP2 with an extra N-terminal cysteine residue
Specificity	This antibody recognizes human peripheral myelin protein 22 (PMP22).
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	peripheral myelin protein 22
Database Link	Entrez Gene 5376 Human UniProt ID Q01453
Background	PMP22 is a 160 amino acid glycoprotein and contains four hydrophobic domains, presumably transmembrane regions. It is the second most abundant protein in the mammalian nervous system, but is, at least in rodents, also found in other tissues, including the liver and gut. Myelin protein zero (P0) is the most abundant protein in mammalian peripheral nerve myelin. An interaction between P0 and PMP22 has been detected in compact myelin. Defects in PMP22 have been related to Charcot-Marie-Tooth disease (CMT) and inflammatory demyelinating neuropathy (IDP). Immunization with PMP22 induces experimental auto-immune neuritis without central nervous inflammation. Therefore, PMP22 is considered as candidate auto-antigen in inflammatory diseases of the peripheral nervous system, including both acute and chronic inflammatory demyelinating polyradiculoneuropathy.
Synonyms	PMP-22, GAS3, GAS-3, Peripheral myelin protein 22
Reference Data

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