ADAMTSL1 Mouse Monoclonal Antibody [Clone ID: 1B2-8-14]

Specifications

Product Data
Clone Name	1B2-8-14
Applications	ELISA, WB
Recommend Dilution	Immunoassay. Western blot (works better in non-reducing than reducing conditions although it will also recognize the reduced antigen at correspondingly higher concentrations).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	Monoclonal antibody 1B2-8-14 reacts with Punctin-1 (ADAMTSL-1). It recognizes the spacer domain and reacts with molecular species of 55 kDa or a doublet of 55 kDa and 60 kDa (glycosylated form). Note that proteolysis of Punctin-1 has been described and additional smaller bands may also be obtained.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	ADAMTS like 1
Database Link	Entrez Gene 92949 Human UniProt ID Q8N6G6
Background	Punctin-1 is a secreted molecule resembling members of the family of proteases designated ADAMTS (a disintegrin-like and metalloprotease domain with thrombospondin type I motif). ADAMTS proteases are secreted enzymes that consist of a metalloprotease domain (which provides the catalytic activity) and ancillary domains (which provide substrate, cell or extracellular matrix activity). Punctin-1 lacks the pro-metalloprotease and the disintegrin-like domain typical of this family but contains other ADAMTS domains in precise order including 4 thrombospondin-I repeats. Punctin-1 is an extracellular matrix protein in tissues and deposited into the cell substratum and localized towards the periphery of transfected cells. Punctin-1 and Punctin-2 (ADAMTSL-3) are the first members of a novel family of ADAMTS-like proteins that appear to have important functions in the extracellular matrix.
Synonyms	ADAMTSL-1, ADAMTSR1, ADAMTS-like protein 1
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.