PROCR Rat Monoclonal Antibody [Clone ID: RCR-252]
CAT#: AM26233FC-N
PROCR rat monoclonal antibody, clone RCR-252, FITC
Conjugation: Unconjugated
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CNY 9,488.00
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Specifications
Product Data | |
Clone Name | RCR-252 |
Applications | FN, IP, WB |
Recommend Dilution | Flow cytometry (1,2): Stains the extracellular domain of human EPCR. As positive control RE-1 cells were used and as negative control N1 cells. (Ref.1). The typical starting working dilution is 1:50. Functional studies (1-4): Blocking antibody. It ablates APC binding to EPCR and blocks APC-mediated signaling. The antibody was functionally tested by pretreatment of cells with 10-25 µg/ml RCR-252 (Ref.1-4). Immunoprecipitation (5). Western blot (5): A non-reduced sample treatment was used. The observed band size is/ 50 kDa (Ref.5): The typical starting working dilution is 1:50. Positive control: RE-1 (rat 3Y1 fibroblasts stably transfected with human EPCR. Negative control: N1-cells. |
Reactivity | Human |
Host | Rat |
Clonality | Monoclonal |
Specificity | The monoclonal antibody RCR-252 recognizes human endothelial protein C receptor (EPCR). |
Formulation | PBS Label: FITC State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 1% bovine serum |
Concentration | lot specific |
Purification | Protein G |
Conjugation | FITC |
Storage Condition | Store at 2 - 8 °C. |
Gene Name | protein C receptor |
Database Link | |
Background | Endothelial protein C receptor (EPCR) is a highly glycosylated type I transmembrane protein of 221-amino-acids. These amino acids comprise an extracellular domain, a 25-aa transmembrane domain, and a short (3 aa) intracytoplasmic sequence coding for an ~46 kDa protein. Deglycosylation will reduce the protein mass to 25 kDa. EPCR is expressed strongly on the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. |
Synonyms | PROCR, Endothelial protein C receptor, APC receptor |
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