Collagen II (COL2A1) Mouse Monoclonal Antibody [Clone ID: CIIC1]

Specifications

Product Data
Clone Name	CIIC1
Applications	ELISA, FN, IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections: The typical starting working dilution is 1/10. Immunohistochemistry on Paraffin Sections: The typical starting working dilution is 1/10. Functional Assays. Immunoassays (Coating + Detection).
Reactivity	Bovine, Chicken, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Specificity	The monoclonal antibody CIICI reacts with the C1 epitope (triple helical position 358-364) of collagen type II. It has been shown to induce CAIA in naïve mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody M2139, binding to the J1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity. The monoclonal antibody CIIC1 is cross reactive with Rat, Bovine, Chicken and Human CII.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA
Concentration	lot specific
Purification	Protein Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	collagen type II alpha 1 chain
Database Link	Entrez Gene 1280 Human UniProt ID P02458
Background	Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA).
Synonyms	COL2, Collagen II
Reference Data

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