MAPT / TAU pThr181 (177-187) Mouse Monoclonal Antibody [Clone ID: 1A4]

CAT#: AM26411PU-L

MAPT / TAU pThr181 (177-187) mouse monoclonal antibody, clone 1A4, Aff - Purified



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CNY 6,120.00


货期*
4周

规格
    • 500 ug

Cited in 1 publication.

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Specifications

Product Data
Clone Name 1A4
Applications WB
Recommend Dilution Western blot
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Immunogen KLH conjugated with a short peptide corresponding to the amino acid sequence 177-187 on the phosphorylated Tau protein
Specificity This antibody recognizes the aa177-187 on phosphorylated Tau protein and its KLH conjugate, but not recognizes KLH alone. The antibody detected a 46kD band in mouse brain tissue lysate.
Formulation 0.01M PBS pH7.2
State: Aff - Purified
State: Lyophilized Ig fraction
Reconstitution Method Double distillated water is recommended to reconstitute the antibody.
Purification Protein G affinity purified
Conjugation Unconjugated
Storage Condition

Store at -20 °C. Avoid repeated freezing and thawing.

Gene Name microtubule associated protein tau
Background Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.
Synonyms MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein, Paired helical filament-tau
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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