CBX1 Mouse Monoclonal Antibody [Clone ID: 1MOD-1A9]

Specifications

Product Data
Clone Name	1MOD-1A9
Applications	IHC
Recommend Dilution	Immunohistochemistry on paraffin sections: 4 µg/ml (1:50). Microwave pretreatment in citrate buffer is recommended for antigen retrieval. Suggested Positive control: Human / Swine brain cortex.
Reactivity	Human, Mouse, Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant mouse HP1β
Specificity	This antibody detects HP1β.
Formulation	Phosphate buffered saline pH 7.2 (PBS) State: Purified State: Lyophilized affinity purified Ig fraction Stabilizer: 5 mg/ml bovine serum albumin (BSA) Preservative: 0.01% Kathon
Reconstitution Method	Reconstitute by adding 0.5 ml distilled water. This stock solution contains 0.2 mg/ml IgG.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	chromobox 1
Database Link	Entrez Gene 10951 Human UniProt ID P83916
Background	Heterochromatin Protein 1 (HP1) ("Chromobox Homolog", CBX) includes three isoforms in mammals, designated α, β, and γ. HP1 proteins are approximately 25 kDa in size. They are highly conserved adapter proteins with important regulatory functions in the cell nucleus. These functions include notably gene silencing by heterochromatin formation. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all Eukaryotic chromosomes. HP1 β and γ also localize to euchromatic sites in the genome. Members of the HP1 family are characterized by an N-terminal chromodomain and a C- terminal chromoshadow domain, separated by a Hinge region. Chromodomain and chromoshadow domain establish secondary interactions with a large number of other proteins. HP1 proteins are subject to multiple types of post - translational modifications, including phosphorylation, acetylation, methylation, ubiquitination and sumoylation, suggesting multiple means of regulation.
Synonyms	Chromobox protein homolog 1, M31, Heterochromatin protein p25, HP1Hsbeta, p25beta, HP1-beta, HP1 beta
Reference Data

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