Alkyl DHAP synthase (AGPS) (158-384) Mouse Monoclonal Antibody [Clone ID: AGPS-03]

Specifications

Product Data
Clone Name	AGPS-03
Applications	FC, WB
Recommend Dilution	Flow cytometry: 1-4 µg/ml. Intracellular staining. Western blot: 1-2 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human AGPS (amino acids 158-384)
Specificity	This antibody recognizes AGPS (alkykglycerone phosphate synthase), an peroxisomal enzyme important for lipid biosynthesis.
Formulation	Phosphate buffered saline (PBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4
Concentration	lot specific
Purification	Protein-A affinity chromatography (>95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	alkylglycerone phosphate synthase
Database Link	Entrez Gene 8540 Human UniProt ID O00116
Background	AGPS (alkylglycerone phosphate synthase), is an enzyme that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetone phosphate (acyl-DHAP) is converted to alkyl-DHAP by addition of a long chain alcohol and removal of a long-chain acid anion. The protein is localized to the inner side of the peroxisomal membrane and requires FAD as a cofactor. Mutations in AGPS gene have been associated with type 3 of rhizomelic chondrodysplasia punctata (RCDP3), and Zellweger syndrome. Higher expression of AGPS was observed in BCR/ABL positive leukemias and it was also described to be associated with higher risk of relapse.
Synonyms	Alkyl-DHAP synthase
Reference Data

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