IL2 Mouse Monoclonal Antibody [Clone ID: B-G5]

Specifications

Product Data
Clone Name	B-G5
Applications	FC, FN, WB
Recommend Dilution	Western Blot. Functional Assay: Blocks IL-2 induced proliferation on CTL-L2 murine cell line. Flow Cytometry (Intra-cytoplasmic).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Natural Human IL-2
Specificity	Recognizes both natural and recombinant Human Interleukin-2 (IL-2).
Formulation	PBS without Carrier and preservatives. This product is Sterile-filtered through 0.22 µm and treated to remove endotoxins. State: Azide Free State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	interleukin 2
Database Link	Entrez Gene 3558 Human UniProt ID P60568
Background	Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.
Synonyms	IL-2, TCGF
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus

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