IL27 Mouse Monoclonal Antibody [Clone ID: B-G49]

Specifications

Product Data
Clone Name	B-G49
Applications	FC
Recommend Dilution	Flow Cytometry on Dendritic cells.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human IL-27.
Specificity	Recognizes both natural and recombinant Human IL-27
Formulation	Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 µm and treated to remove Endotoxins. State: Azide Free State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	interleukin 27
Database Link	Entrez Gene 246778 Human UniProt ID Q8NEV9
Background	Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.
Synonyms	IL-27 subunit alpha, IL27-A, p28, IL30, IL-30, Interleukin-30
Reference Data
Protein Families	Druggable Genome, Transmembrane

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