CEACAM1 Mouse Monoclonal Antibody [Clone ID: B-D60]

Specifications

Product Data
Clone Name	B-D60
Applications	FC
Recommend Dilution	Flow Cytometry: Use 10 µl to label 106 cells or 100 µl of whole blood.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Skin derived T cell clone
Specificity	This antibody recognises CD66a, a 160 kDa protein.
Formulation	PBS Label: FITC State: Liquid purified IgG fraction Stabilizer: 5% BSA Preservative: 0.09% Sodium Azide Label: Fluorescein isothiocyanat
Purification	Ion Exchange Chromatography
Conjugation	FITC
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	carcinoembryonic antigen related cell adhesion molecule 1
Database Link	Entrez Gene 634 Human UniProt ID P13688
Background	CEACAM1 (BGP/CD66a) is a transmembrane glycoprotein which belongs to the carcinoembryonic antigen (CEA) gene family. It is expressed on cells of epithelial and myeloid origin and mediates homophilic intercellular interactions that influence cellular growth, immune cell activation, and tissue morphogenesis. CEACAM1 is a putative tumour suppressor based on diminished expression in some aggressive types of cancer cells. The anti-tumour effect may be due to inhibition of tumour angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM.
Synonyms	BGP, BGP1, Biliary glycoprotein 1
Reference Data
Protein Families	Druggable Genome, Transmembrane

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