IL31 Mouse Monoclonal Antibody [Clone ID: B-A51]

CAT#: AM31281AF-N

IL31 mouse monoclonal antibody, clone B-A51, Azide Free



Need it in bulk or conjugated?
Get a free quote

CNY 7,183.00


货期*
5周

规格
    • 500 ug

Product images

Specifications

Product Data
Clone Name B-A51
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Recombinant human IL-31
Specificity This antibody recognises recombinant IL-31.
Formulation Phosphate-buffered saline.
Sterile-filtered through 0.22 µm.
Carrier and preservative free
State: Azide Free
State: Liquid purified Ig fraction
Concentration lot specific
Purification Ion exchange chromatography
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C.
Gene Name interleukin 31
Background Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia and skin lesions, and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
Synonyms IL-31
Reference Data
Protein Families Secreted Protein, Transmembrane
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...