MRP8 (S100A8) Mouse Monoclonal Antibody [Clone ID: CF-145]

Specifications

Product Data
Clone Name	CF-145
Applications	FC, IF, IHC, WB
Recommend Dilution	Flow Cytometry: 0.5 µg/1x10e6 cells. Immunofluorescence. Western blot. Immunohistochemistry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified granulocyte antigen of Human origin.
Specificity	This antibody detects Calgranulin A (S100A8).
Formulation	PBS containing 0.02% Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. Label: Biotin State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Protein G Chromatography of Ascitic fluid.
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	S100 calcium binding protein A8
Database Link	Entrez Gene 6279 Human UniProt ID P05109
Background	Calgranulin A, also known as MRP-8 and S100A8 is a member of the S100 family of proteins containing 2 EF hand (alpha helix, turn, alpha helix structure) calcium binding motifs. S100 proteins are localized in the cytoplasm and /or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. MRP-8 (S100A8) forms a heterodimeric complex with Calgranulin B, (MRP-14, S100A9) in the cytosol of monocyte and neutrophil cell types circulating in peripheral blood. Calgranulin A is found in elevated levels in the serum of cystic fibrosis cases and is also expressed in the skin of patients with psoriasis, eczematous dermatitis and squamous cell carcinoma.
Synonyms	S100-A8, CAGA, MRP-8, CFAG
Reference Data

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