Cd27 Hamster Monoclonal Antibody [Clone ID: LG.3A10]

Specifications

Product Data
Clone Name	LG.3A10
Applications	FC, FN, IHC
Recommend Dilution	Flow Cytometry. Functional studies (stimulating).  Immunohistochemistry on Frozen Sections. Tissue Distribution by Flow Cytometry Analysis: Mouse Strain: BALB/c Cell Concentration : 1x106 cells per tests Antibody Concentration Used: 0.5 μg/106 cells Isotypic Control: PE Hamster IgG
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	MCD27 tag expressing clones AR0524 and AR0530 Donor: Armenian hamster spleen Fusion Partner: SP2/0 Murine Myeloma Partner
Specificity	This Monoclonal Antibody is specific for the Mouse CD27 receptor.
Formulation	PBS Label: Biotin State: Liquid purified IgG fraction Stabilizer: EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml Preservative: 0.02% Sodium Azide
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD27 antigen
Database Link	Entrez Gene 21940 Mouse UniProt ID P41272
Background	CD27 is part of the Tumor Necrosis Factor (TNF) family of receptors and is lymphocyte specific. Murine CD27 is expressed on the great majority of both αβ and γδ T lymphocytes, on a small population of peripheral B cells and on a very small subset of B220+ cells in the bone marrow. Murine CD27 is found on all thymocytes except a subset of CD4-CD8-precursors. There are two known basic functions of CD27 signaling. First, the binding of CD27 to CD70, a protein which is also expressed in T and B cells, provides costimulatory signals in lymphocyte proliferation and immunoglobulin production. Second, the association of CD27 with intracellular Siva, a proapoptotic protein, results in the induction of apoptotic events.
Synonyms	TNFRSF7, CD27L receptor, T14
Reference Data

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