Pdcd1 Hamster Monoclonal Antibody [Clone ID: J43]

CAT#: AM31881RP-N

Pdcd1 hamster monoclonal antibody, clone J43, PE

Conjugation: Unconjugated Biotin FITC PE



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CNY 3,700.00


货期*
5周

规格
    • 50 ug

Product images

Specifications

Product Data
Clone Name J43
Applications FC
Recommend Dilution Flow Cytometry.
Reactivity Mouse
Host Hamster
Clonality Monoclonal
Immunogen PD-1 cDNA transfectant.
Donor: mouse ascites fluid.
Fusion Partner: Mouse myeloma P3U1.
Specificity This Monoclonal Antibody reacts with Mouse PD-1 (Programmed Death-1).
Formulation PBS containing 0.02% Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
Label: PE
State: Liquid purified IgG fraction
Label: R - Phycoerythrin
Concentration lot specific
Purification Protein G Chromatography
Conjugation PE
Storage Condition Store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
Gene Name programmed cell death 1
Background CD279 is 50-55kD membrane protein which is a member of the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation. Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion.
Synonyms Protein PD-1, hPD-1, PDCD1
Note TEST RESULTS (Figure 1.)
Tissue Distribution by Flow Cytometry Analysis:
Mouse Strain: Balb/c
Antibody Concentration Used: 2.0 µg/10e6 cells.
Isotypic Control (shaded): Purified Hamster IgG.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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