Tnfrsf1b Rat Monoclonal Antibody [Clone ID: HM102]

Specifications

Product Data
Clone Name	HM102
Applications	ELISA, FC, IHC, IP
Recommend Dilution	Immunoassays. Immunoprecipitation. Flow Cytometry: Use 1/10 as starting working dilution. immunohistochemistry on Frozen Sections: Use 1/10 as starting working dilution.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Specificity	The antibody reacts with the extra-cellular part of the Mouse TNF-RII and with the soluble receptor. TNF-RII is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha. The TNF-RII molecule is shown to be responsible for stimulation of activated T-lymphocytes by TNF-alpha. The reactivity of the antibody with soluble TNF-Receptor is not inhibited by high concentrations of Mouse TNF-alpha.
Formulation	PBS State: Aff - Purified State: Liquid purified IgG fraction (≥ 98% pure by SDS PAGE). Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein G. Product is 0.22 μm Membrane filtered.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tumor necrosis factor receptor superfamily, member 1b
Database Link	Entrez Gene 21938 Mouse UniProt ID P25119
Background	Tumor Necrosis Factor (TNF) is a cytokine whose function is mediated through two distinct cell surface receptors (TNF Receptor I and TNF Receptor II) that are included in the TNF receptor superfamily along with FAS antigen and CD40. TNF receptors I and II are membrane glycoproteins and they are from the family of cell surface molecules including nerve growth factor receptor, Fas/Apo1, CD30, OX40, and 4-1BB, which are characterized by cysteine rich motifs in the extracellular domain. TNF Receptor II (p75, CD120b) is present on most cell types (including monocytes, endothelial cells, Langerhans cells, and macrophages) and is considered to play a role in cell stimulation by TNF alpha. TNF Receptor II molecule is shown to be responsible for stimulation of activated T lymphocytes by TNF alpha.
Synonyms	Tumor necrosis factor receptor 2, p80 TNF-alpha receptor, TNFRSF1B, TNFBR, TNF-R2
Reference Data

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