Pepsinogen II (PGC) Mouse Monoclonal Antibody [Clone ID: L10CC10]

Specifications

Product Data
Clone Name	L10CC10
Applications	ELISA, IHC, WB
Recommend Dilution	Western blotting Enzyme Immunoassays. Immunohistochemistry on Paraffin Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Pepsinogen II purified from Human tissue. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Specificity	The antibody clone L10CC10 is specific to Human Pepsinogen II and has no crossreactivity to Human Pepsinogen I.
Formulation	PBS State: Ig Fraction State: Liquid Ig fraction Stabilizer: 1.0% BSA Preservative: 0.09 % Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	progastricsin (pepsinogen C)
Database Link	Entrez Gene 5225 Human UniProt ID P20142
Background	Pepsinogen II is a group of precursor molecules for pepsin. These proteins are secreted into the gastric lumen by the pyloric glands of the gastric antrum and also by the chief and neck cells of the gastric corpus (oxyntic mucosa). Negative immunohistochemical reaction for pepsinogen I (right) but positive reaction for pepsinogen II (left) is a typical sign of the antral mucosa and, in the presence of atrophic gastritis, this staining pattern indicates that the positive glands and cells are metaplastic and “pyloric” in differentiation (so called pseudopyloric metaplasia).
Synonyms	Pepsinogen C, Progastricsin, Gastricsin, PGC
Reference Data

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