CD46 (SCR2 Dom.) Mouse Monoclonal Antibody [Clone ID: M177]

Specifications

Product Data
Clone Name	M177
Applications	ELISA, FN, IHC, IP, WB
Recommend Dilution	Flow Cytometry. Immunoassay. Immunohistochemistry on frozen and paraffin sections. Immunoprecipitation. Western blot.  Instructions for use For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1/10.  For inhibition of biological  activity in vitro dilutions have to be made according to the amounts of CD46 to be inactivated.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	The monoclonal antibody M177 reacts with the SCR2 domain of CD46.
Formulation	PBS State: Liquid State: Liquid purified Ig fraction Stabilizer: 0,1% BSA
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	CD46 molecule
Database Link	Entrez Gene 4179 Human UniProt ID P15529
Background	CD46, also designated membrane cofactor protein, is a 45-70 kDa protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to down-regulate the activation of complement on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. The isoforms differ in the length. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)).
Synonyms	TLX, MIC10
Reference Data

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