Rat Tumors, epithelial origin Mouse Monoclonal Antibody [Clone ID: CC52]

Specifications

Product Data
Clone Name	CC52
Applications	ELISA, IHC, IP, WB
Recommend Dilution	ELISA.  Western blotting.  Flow Cytometry. Immunoprecipitation. Immunohistochemistry on Frozen Sections.  Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Tissue: There is some cross reactivity with intestinal epithelial tissue and bile ducts. Citric acid pretreatment is recommended.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Immunization of mice with Rat colon adenocarcinoma cells (CC531).
Specificity	CC52 is a Rat strain-independent marker for tumour cells of epithelial origin, such as colon, breast, or lung cancer, etc. When injected in colon tumour-bearing rats, CC52 localized to tumour cells (Hagenaars et al., 2001).  CC52 has been used in many studies in a rat model of colorectal cancer (Hagenaars et al., 2000). This Monoclonal antibody clone CC52 belongs to a first generation of such antibodies and is suitable to detect tumour cells by Immunohistochemistry.  It binds to a dimer of two proteins, 120 kD and 130 kD, expressed by Rat tumour cells of epithelial origin.  The antigens detected by CC52 are also expressed by IL-2-activated cultured NK cells and T cells and by bone marrow cells.
Formulation	State: Purified State: Liquid purified Ig fraction Preservative: 0.05% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for Two months or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	Common epithelial tumors begin in the surface epithelium of the ovaries and account for about 90% of all ovarian cancers. They are divided into a number of subtypes - including serous, endometrioid, mucinous, and clear cell tumors - that can be further classified as benign (noncancerous) or malignant (cancerous) tumors.
Synonyms	Rat Tumor Marker
Reference Data

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