Lipid A Mouse Monoclonal Antibody [Clone ID: 26-5]
CAT#: AM32312SU-N
Lipid A mouse monoclonal antibody, clone 26-5, Purified
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CNY 3,661.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | 26-5 |
Applications | AGG, ELISA |
Recommend Dilution | ELISA. Agglutination assays. Recommended Dilutions: For ELISA use a dilution of 1/10 in PBS containing 4% BSA and 0.05% Tween. For Agglutination Tests: The antibody should be used undiluted. For ELISA prepare bacteria suspension in PBS (5x108 bact. /ml). Coat ELISA plate with 100 μl/well for 1 h. at 37°C, store overnight at 4°C and wash 5x with tap water with 0.05% Tween (TT). Incubate with diluted antibody, 1 h. at 37°C. Wash 5x with TT. Incubate with appropriate conjugate (anti-Mouse Ig Enzyme labeled antibody). Add substrate solution, incubate, stop reaction and read optical density. |
Reactivity | Gram Negative Bacteria |
Host | Mouse |
Clonality | Monoclonal |
Specificity | This Monoclonal antibody is reactive with Lipid A using ELISA. |
Formulation | PBS State: Purified State: Liquid (0.2 µm filtered) purified Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C. |
Background | Lipid A is part of a Gram-negative bacterial endotoxin located at one end of the lipopolysaccharide (LPS) molecule. Lipid A is made up of two glucosamine units with attached acyl chains, and it usually contains one phosphate group on each carbohydrate. Lipid A functions to anchor the LPS to the outer membrane of a Gram-negative bacteria. The toxicity of Gram-negative bacteria is due to Lipid A since this is what the human immune system recognizes, though this recognition is also critical for the onset of immune responses to Gram-negative infection and for the subsequent successful fight against the infection. Lipid A may play a role in to activating cells via Toll-like receptor 4 (TLR4), MD-2, and CD14 on the cell surface. When present in the body at high concentrations during a Gram-negative bacterial infection, Lipid A can cause shock and death because it is such a potent immune system activator. |
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