Influenza A H1N1 Mouse Monoclonal Antibody [Clone ID: 14B11]

Specifications

Product Data
Clone Name	14B11
Applications	ELISA, IF, WB
Recommend Dilution	ELISA. Western Blot: 1/500-1/5000. Immunofluorescence: 1/200-1/1000.
Reactivity	Influenza A Virus
Host	Mouse
Clonality	Monoclonal
Immunogen	Inactivated H1N1 virion
Specificity	Reacts with H1N1 Influenza A virus.
Formulation	0.1M Tris, 0.1M Glycine, 2% Sucrose State: Purified State: Lyophilized powder Preservative: None
Reconstitution Method	Restore with distilled water
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Background	Influenza type A viruses are divided into subtypes based on the antigenic differences of two viral surface proteins, hemagglutinin (H) and neuraminidase (N). On infection of the respiratory tract, the hemagglutinin molecule binds to sialic acid-containing receptors on the epithelial cells resulting in endocytosis. Once the virus has been engulfed, the hemagglutinin allows the viral membrane to fuse with the endosomal membrane. Neuraminidase functions to aid viral release from host cells by cleaving terminal sialic acid residues from carbohydrate moieties on the cell surface. Subtype antigenic variations result from a process known as antigenic drift whereby these surface proteins constantly mutate in order to evade the host immune repspone. Subtype A(H1N1) was the cause of Spanish flu that killed approximately 500,000 people between 1918-1919.
Synonyms	Seasonal Flu H1N1
Reference Data

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