Lactoferrin (LTF) Mouse Monoclonal Antibody [Clone ID: 67D9]

Specifications

Product Data
Clone Name	67D9
Applications	IHC, WB
Recommend Dilution	Western blot. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections. Positive Control: Human Spleen, Neutrophils; lactating mammary gland sections.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Milkfat globule membranes.
Specificity	Monoclonal antibodies 67D2, 67D9 and 67F12 bind to the same or overlapping epitopes on an 80 Kd antigen indicated as MAM-5. On frozen as well as on formalin-fixed lactating mammary gland sections, a very strong reaction in secretion products is observed. Occasionally, preexisting ducts react in some of the mammary tumors, indicating an enhanced secretory activity in these parts of the mammary gland.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	lactotransferrin
Database Link	Entrez Gene 4057 Human UniProt ID P02788
Background	Lactoferrin (LF), also known as lactotransferrin (LTF), is a multifunctional protein of the transferrin family. Lactoferrin is a globular glycoprotein with a molecular mass of about 80 kDa that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. Lactoferrin is also present in secondary granules of polymorphonuclear neutrophils (PMN) and is secreted by some acinar cells. The diagnosis and classification of human breast carcinomas is mainly based on morphology, which has its difficulties and limitations. Specific markers for breast tumors and additional markers, to correlate with the progress of the disease, are needed. Antibodies to human milk-fat globule (HMFG) membranes are such potential markers for breast carcinomas. HMFG membranes carry differentiation antigens of the apical site of the secretory cell which may be present also on tumor cells.
Synonyms	LTF, LF, Lactoferrin, EC=3.4.21, Talalactoferrin
Reference Data

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