c-Myc (MYC) Mouse Monoclonal Antibody [Clone ID: MYC699]
CAT#: AM33353PU-S
c-Myc (MYC) mouse monoclonal antibody, clone MYC699, Purified
Size: 20 ug
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CNY 5,606.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | MYC699 |
Applications | FC, IF, IHC, IP, WB |
Recommend Dilution | ELISA: Use BSA free Antibody for coating. Flow Cytometry: 0.5-1 μg/million cells. Immunofluorescence: 1-2 μg/ml. Western Blotting: 0.5-1 μg/ml. Immunoprecipitation: 1-2 μg/500 μg protein lysate. Immunohistochemistry on Frozen Sections: 0.5-1.0 μg/ml for 30 minutes at RT. Positive Control: HL-60 cells or breast carcinoma. |
Reactivity | Chimpanzee, Human, Gorilla |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQL-RNSCA) from C-terminus of Human c-myc, coupled to KLH. |
Specificity | Recognizes c-Myc Oncoprotein. Cellular Localization: Nuclear. |
Formulation | 10mM PBS State: Purified State: Liquid purified IgG fraction from Bioreactor Concentrate Stabilizer: 0.05% BSA Preservative: 0.05% Sodium Azide |
Concentration | lot specific |
Purification | Protein A/G Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. |
Predicted Protein Size | 62-64 kDa |
Gene Name | v-myc avian myelocytomatosis viral oncogene homolog |
Database Link | |
Background | The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiatio n, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/ Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase ( JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c -Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribut e blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment. |
Synonyms | Transcription factor p64, BHLHE39 |
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