PNPO Mouse Monoclonal Antibody [Clone ID: AT2C7]

Specifications

Product Data
Clone Name	AT2C7
Applications	ELISA, WB
Recommend Dilution	ELISA. Western blot (1:500 - 1:5000).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human PNPO (57-261aa) purified from E. coli
Specificity	Teh antibody recognizes human PNPO. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	pyridoxamine 5'-phosphate oxidase
Database Link	Entrez Gene 55163 Human UniProt ID Q9NVS9
Background	PNPO (pyridoxamine 5'-phosphate oxidase) is a 261 amino acid protein belonging to the pyridoxamine 5'-phosphate oxidase family. It is the rate-limiting enzyme in vitamin B6 synthesis. Vitamin B6 (Pyridoxal 5-prime-phosphate or PLP) is vital for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine.
Synonyms	FLJ10535; PDXPO
Reference Data
Protein Pathways	Metabolic pathways, Vitamin B6 metabolism

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