Cd5 Mouse Monoclonal Antibody [Clone ID: HIS47]
CAT#: AM39067SU-N
Cd5 mouse monoclonal antibody, clone HIS47, Supernatant
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CNY 3,939.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | HIS47 |
Applications | IF, IHC |
Recommend Dilution | Flow cytometry. Immunofluorescence. Immunohistochemistry on frozen sections. |
Reactivity | Rat |
Host | Mouse |
Clonality | Monoclonal |
Specificity | The antibody recognizes peripheral T lymphocytes and thymocytes (CD5). In rats, a CD5+ subset of B lymphocytes has not beem characterized. |
Formulation | State: Supernatant State: Liquid cell culture supernatant containing 0.09% sodium azide |
Conjugation | Unconjugated |
Storage Condition | Store undiluted a 2-8°C. |
Gene Name | Cd5 molecule |
Database Link | |
Background | CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, (human) subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD72 is the major ligand for CD5. |
Synonyms | CD5, LEU1 |
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