DIABLO Mouse Monoclonal Antibody [Clone ID: AT19F2]

Specifications

Product Data
Clone Name	AT19F2
Applications	ELISA, WB
Recommend Dilution	The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:3000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human SMAC/Diablo (56-239aa) purified from E. coli
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	diablo IAP-binding mitochondrial protein
Database Link	Entrez Gene 56616 Human UniProt ID Q9NR28
Background	SMAC/Diablo is one of the proapoptotic proteins. SMAC promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding to inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. In healthy cells, SMAC is a mitochondrial protein, but when cells undergo apoptosis, SMAC is released into the cytosol. SMAC is ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes
Synonyms	0610041G12Rik; DIABLO-S; FLJ10537; FLJ25049; SMAC; SMAC3
Reference Data
Protein Families	Transmembrane

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