PLGF (PGF) Mouse Monoclonal Antibody [Clone ID: PLGF94]

Specifications

Product Data
Clone Name	PLGF94
Recommend Dilution	ELISA: Use BSA free Antibody for coating. Functional Studies: Use Antibody without BSA & Azide. Positive Control: HepG2 cells or human placental and brain tumors.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human PLGF protein.
Specificity	The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include fibroblast growth factor (FGF), platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). Like VEGF, several PlGF vari- ants have been shown to arise from alternative mRNA splicings. Evidence has suggested VEGF to be an obligatory component in PlGF signaling. While VEGF homodimers and VEGF/PlGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PlGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PlGF. VEGF and PlGF share a common receptor, Flt-1, and may also activate Flk-1/KDR. Cellular Localization: Secreted (extracellular).
Formulation	10mM PBS State: Purified State: Liquid purified IgG fraction from Bioreactor Concentrate Stabilizer: 0.05% BSA Preservative: 0.05% Sodium Azide
Concentration	lot specific
Purification	Protein A/G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Predicted Protein Size	18 kDa
Gene Name	placental growth factor
Database Link	Entrez Gene 5228 Human UniProt ID P49763
Synonyms	PGFL, PLGF, PlGF
Reference Data

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