Versican core protein / VCAN (362-585) Mouse Monoclonal Antibody [Clone ID: S351-23]

Specifications

Product Data
Clone Name	S351-23
Applications	IF, WB
Recommend Dilution	Western Blot: 1 μg/ml of this antibody was sufficient for detection of Versican core protein / VCAN in 20μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG-HRP as the secondary antibody. Immunocytochemistry.
Reactivity	Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein, amino acids 362-585 (glycosaminoglycan alpha domain) of mouse Versican core protein / VCAN
Specificity	This antibody detects Versican core protein / VCAN (aa362-585); >350 kDa.
Formulation	PBS pH 7.4, 50% Glycerol State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium azide
Concentration	lot specific
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Database Link	UniProt ID Q62059
Background	Versican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a Lectinlike sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length and degree of modification by glycoaminoglycan chains.  Accumulation around smooth muscle cells in lesions of athero-sclerosis suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may faciliatate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels.
Synonyms	CSPG2, GHAP, PG-M
Reference Data

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