Adenovirus Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, WB
Recommend Dilution	ELISA. Immunofluorescence. Western Blot.
Reactivity	Adeno-Associated Virus 2, Adeno-Associated Virus 3, Adeno-Associated Virus 4, Adeno-Associated Virus 5, Adeno-Associated Virus 6
Host	Goat
Clonality	Polyclonal
Immunogen	Disrupted type 5 virions
Specificity	This Adenovirus antibody reacts to Numerous Adenovirus proteins including hexon. Reacts with Adenovirus types 2, 3, 4, 5 and 6. Does not crossreact with Para 1-3, Influenza A & B, RSV, human MPV & Rhinovirus (type 16). Negative against HEp-2, LLCMK2 and Vero cells by indirect immunofluorescence.
Formulation	0.01M PBS, pH 7.2 Label: FITC State: Liquid Ig fraction Stabilizer: 10mg/ml BSA Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	FITC
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should protected from light. Avoid repeated freezing and thawing.
Background	Adenoviruses are DNA viruses generally widespread in nature that are frequently the cause of acute upper respiratory tract infections (i.e. common colds). Forty-seven known serotypes have been isolated since they were first discovered in 1953 with 3 types known to cause gastroenteritis. Several types have oncogenic potential though most cause self-limiting febrile illnesses characterised by inflammation of conjunctivae and the respiratory tract. The virus can be isolated from the majority of tonsils/adenoids surgically removed, indicating latent infections. It is not known how long the virus can persist in the body, or whether it is capable of reactivation after long periods. In patients experiencing immunosuppression (e.g. AIDS) it can be reactivated causing disease. The adenovirus early gene products E1A is a potent stimulator of cellular proliferation, which when overexpressed can overcome the growth inhibitory effects of TGF beta. The E1A region encodes a series of related proteins (35 - 46 kD) with multifunctional capabilities and forms a specific complex with the retinoblastoma tumor suppressor gene product. The E1a and E1B regions together comprise the transforming region of adenovirus. While expression of E1A alone is sufficient to immortalize primary cells, complete transformation requires the additional expression of the E1B region.
Note	Centrifuge before opening to ensure complete recovery of vial contents.
Reference Data

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