ASK1 (MAP3K5) pSer83 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1:20000~1:40000. WB: 1:500~1:1000. IHC: 1:50~1:200.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Specificity	p-ASK1 (pSer83) antibody detects endogenous levels of p-ASK1 protein.
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. State: Aff - Purified State: Liquid purified Ig
Concentration	1,0 mg/ml
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	mitogen-activated protein kinase kinase kinase 5
Database Link	Entrez Gene 4217 Human UniProt ID Q99683
Background	Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli including growth factors. The MEK kinases (also called MAP kinase kinase kinases) phosphorylate and activate the MAP kinases including ERK, JNK and p38. The MEK kinases characterized to date include Raf-1, Raf-B, MOS, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (also designated MEK kinase-5). MEK kinase-1 has been shown to phosphorylate MEK-1 via a Raf-independent pathway. Evidence suggests that MEK-3 is preferentially activated by MEK kinase-3 and that MEK-4 is activated by both MEK kinase-2 and MEK kinase-3. MEK kinase-4 has been shown to specifically activate the JNK pathway. ASK 1 activates both MEK-4 and MEK-3/MEK-6 pathways. ASK 1 Serine 83 is phosphorylated by Akt.
Synonyms	MAPK/ERK kinase kinase 5, MAPKKK5, MAP3K5
Reference Data

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