PAI1 (SERPINE1) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, R
Recommend Dilution	ELISA. RIA. Immunohistochemistry on Frozen Sections: 1/50-1/100. Immunohistochemistry on Paraffin Sections: 1/50 (Pretreatment with 0.05% Pronase E for 20 minutes recommended).
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Purified human PAI-1
Specificity	This antibody detects PAI 1. There were no cross reactivities obtained with human tPA ; uPA; and PAI-2.
Formulation	50mM TRIS, pH 7.4 containing 0.04% Thimerosal as preservative. State: Purified State: Lyophilized purified IgG fraction.
Reconstitution Method	Restore in aqua bidest to 1 mg/ml.
Purification	Protein G Chromatography.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing.
Gene Name	serpin family E member 1
Database Link	Entrez Gene 5054 Human UniProt ID P05121
Background	PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.
Synonyms	Serpin E1, PLANH1, Plasminogen Activator Inhibitor 1, PAI-1, PAI
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Complement and coagulation cascades, p53 signaling pathway

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.