VAMP1 Sheep Polyclonal Antibody

Specifications

Product Data
Applications	IP, WB
Recommend Dilution	Western Blot: 1-10 µg/ml. Immunoprecipitation: 5-15 µg/ml. Positive Control: Rat synaptic vesicles.
Reactivity	Human, Rat
Host	Sheep
Clonality	Polyclonal
Immunogen	Full length VAMP1/2 protein
Specificity	This antibody reacts to VAMP 1/2.
Formulation	PBS with 0.08% Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ammonium Sulfate Precipitation
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	vesicle associated membrane protein 1
Database Link	Entrez Gene 6843 Human UniProt ID P23763
Background	Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis. VAMP (also know as synaptobrevin) is part of the synaptic vesicle docking and fusion complex and plays a central role in neuroexocytosis. Two VAMP (vesicle-associated membrane protein) isoforms are expressed in the nervous system and are differently distributed among the specialized parts of the tissue. VAMP-1 and -2 are present in all tissues tested, including kidney, adrenal gland, liver, pancreas, thyroid, heart, and smooth muscle. The two isoforms are differentially expressed in various tissues and their level may depend on differentiation. VAMP-1 is restricted to exocrine pancreas and to kidney tubular cells, whereas VAMP-2 is the predominant isoform present in Langerhans islets and in glomerular cells. Both isoforms show a patchy vesicular intracellular distribution in confocal microscopy. Evidence for the importance of neuronal VAMPproteins in the physiology of all cells is indicated.
Synonyms	Vesicle associated membrane protein 1 and 2, VAMP-1/2
Reference Data

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