PPAR alpha (PPARA) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA: 1:8000 - 1:32000. Western Blot: 1:500 - 1:1000; detects a band of approximately 52kDa in 3T3 whole cell lysate.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to amino acids 1-18 of human PPAR alpha.
Specificity	This antibody detects an epitope within the N-terminal region of human peroxisome proliferator-activated receptor, alpha (PPARA).
Formulation	Phosphate buffered saline pH7.2 containing 0.09% Sodium Azide (NaN3) State: Purified State: Liquid purified IgG
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	peroxisome proliferator activated receptor alpha
Database Link	Entrez Gene 5465 Human UniProt ID Q07869
Background	PPARA is a member of the nuclear hormone receptor subfamily. Upon activation, PPARA forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. In particular, PPARA controls genes involved in the peroxisomal and mitochondrial beta oxidation pathways, fatty acid uptake, and triglyceride catabolism in the liver and skeletal muscle. PPARA also has anti-inflammatory and anti-proliferative effects and prevents the proatherogenic effects of cholesterol accumulation in macrophages by stimulating cholesterol efflux. PPARA is the main target of fibrate drugs; hypolipidemic agents used in the treatment of dyslipidemia and the prevention of cardiovascular disease. They could also be used for the treatment of type II diabetes.
Synonyms	NR1C1, PPAR, PPARA
Reference Data

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