Neurokinin 3 Receptor NK3 (TACR3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot: 0.5-1.0 µg/ml. Detects a band of approximately 46kDa in RAW264.7 cell lysates. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Antigen retrieval heat treatment (Sodium citrate buffer, pH 6.0) prior to staining of paraffin sections is required.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	An 18 amino acid peptide from near the centre of Human TACR3.
Specificity	This antibody recognises TACR3 otherwise known as NK3 Receptor (NK3R), a 52.2 kDa multi-pass membrane protein belonging to the G-protein coupled receptor 1 family. This antibody does not recognise NK1R or NK2R.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.02% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for up to one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tachykinin receptor 3
Database Link	Entrez Gene 6870 Human UniProt ID P29371
Background	TACR3 is a receptor for the tachykinin neuropeptide, neuromedin-k otherwise known as neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system, and it is likely that these signals lead to the release of vasopressin and oxytocin into the circulation. Studies with mice indicate that TACR3 is involved in learning and memory.
Synonyms	TAC3R, Neuromedin-K receptor, NKR, Neurokinin B receptor, NK-3 receptor, NK-3R, NK3R
Reference Data

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