ADAM10 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	Western blot: 1/1000. Immunocytochemistry.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide corresponding to amino acids 732-748 of Human CDw156C.
Specificity	This antibody recognizes the C-terminal region of the meltalloprotease-disintegrin ADAM-10, also known as CDw156C.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	ADAM metallopeptidase domain 10
Database Link	Entrez Gene 102 Human UniProt ID O14672
Background	ADAM-10 is a member of the mammalian ADAM family and is involved in the cleavage of TNF alpha, Notch and its ligand delta. ADAM-10 mRNA is expressed in a variety of human tissues. Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM-10, CDw156, Mammalian disintegrin-metalloprotease, CD156c or Kuzbanian protein homolog. CD156c is a 748 amino acid ~85 kDa type I, single pass transmembrane glycoprotein with a 19 aa signal peptide and adjacent 194 aa propeptide region yeilding a mature 535 aa protease. CD156c is a member of the mammalian ADAM family and is involved in the cleavage of TNF alpha, Notch and its ligand delta (Primakoff & Miles 2000)
Synonyms	KUZ, MADM, Kuzbanian protein homolog
Reference Data

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