p53 (TP53) pSer392 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1:1000; recognises a band of approximately 53kD in rat brain nuclear fraction lysates.
Reactivity	Human, Monkey, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide corresponding to an amino acid sequence within p53 which includes phosphorylated Ser392.
Specificity	This antibody is specific for p53, when phosphorylated at serine 392.
Formulation	10mM HEPES, pH7.5 containing 0.09% Sodium Azide, 0.01% Bovine Serum Albumin and 50% Glycerol State: Purified State: Liquid purified Ig
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tumor protein p53
Database Link	Entrez Gene 24842 RatEntrez Gene 716170 MonkeyEntrez Gene 7157 Human UniProt ID P04637
Background	The tumour suppressor protein p53, is expressed ubiquitously and plays an important role in blocking proliferation of damaged cells. Phosphorylation of p53 at serine 392 is reported in response to diverse stresses, for example UV irradiation.
Synonyms	Cellular tumor antigen p53, Tumor suppressor p53, Phosphoprotein p53, NY-CO-13
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Amyotrophic lateral sclerosis (ALS), Apoptosis, Basal cell carcinoma, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, Glioma, Huntington's disease, MAPK signaling pathway, Melanoma, Neurotrophin signaling pathway, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer, Thyroid cancer, Wnt signaling pathway

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