17-alpha-Hydroxyprogesterone / 17-OHP Sheep Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA.
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Immunogen	17-Alpha-Hydroxyprogesterone-3-CMO conjugated to KLH
Specificity	This antibody recognizes 17-Alpha-Hydroxyprogesterone-3-CMO, a progestogen which may reduce the risk of pre-term delivery in pregnant women.  17-alpha-Hydroxyprogesterone-3-Cmo Antibody has the following reactivities: 17-Alpha-Hydroxyprogesterone: 100% 11-Deoxycortisol: <2% Progesterone: <1%
Formulation	State: Serum State: Liquid Serum containing 0.09% Sodium Azide as preservative.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	17-Hydroxyprogesterone (17-OH progesterone or 17OHP) is a C-21 steroid hormone produced during the synthesis of glucocorticoids and sex steroids. It is derived from progesterone via 17-hydroxylase, a P450c17 enzyme, or from 17-hydroxypregnenolone via 3-beta-hydroxysteroid dehydrogenase / Delta 5-4 isomerase.  17-Hydroxyprogesterone is a natural progestogen, and in pregnancy increases in the third trimester primarily due to fetal adrenal production. This hormone is primarily produced in the adrenal glands and to some degree in the gonads, specifically the corpus luteum of the ovary. Hydroxyprogesterone  has been used for recurrent miscarriage and various menstrual disorders. Women who have had a spontaneous preterm delivery are at greatly increased risk for preterm delivery in subsequent pregnancies. The results of several small trials have suggested that hydroxyprogesterone may reduce the risk of preterm delivery.
Synonyms	17OHP, 17-Hydroxyprogesterone, 17-alpha-Hydroxy-Progesterone
Reference Data

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