SMAD4 Rabbit Polyclonal Antibody
CAT#: AP06725PU-S
SMAD4 rabbit polyclonal antibody, Aff - Purified
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CNY 800.00
货期*
2周
规格
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200. |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 12-64 of Human Smad4. |
Specificity | This antibody detects endogenous levels of Smad4 protein. (region surrounding Leu43) |
Formulation | Phosphate buffered saline, pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% Sodium Azide |
Concentration | 1.0 mg/ml |
Purification | Immunoaffinity Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | ~ 60 kDa |
Gene Name | SMAD family member 4 |
Database Link | |
Background | Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MadH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad family members. |
Synonyms | SMAD family member 4, SMAD-4, SMAD 4, MADH4, MAD homolog 4, DPC4 |
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