RANKL (TNFSF11) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 0.25 - 0.5 µg/ml.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	14 amino acid synthetic peptide from near the center of Human TNFSF11 / RANKL.
Specificity	This antibody reacts with a 14 amino acid peptide from near the center of sRANK-L.
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tumor necrosis factor superfamily member 11
Database Link	Entrez Gene 8600 Human UniProt ID O14788
Background	OPG ligand (OPGL,) a type II membrane protein, binds to a unique hematopoietic progenitor cell that is committed to the osteoclast lineage and stimulates the rapid induction of genes involved in osteoclast development. OPGL is expressed in the primitive mesenchymal cells, in hypertrophying chondrocytes and in areas undergoing primary ossification and modeling. This gene was independently isolated and called RANKL (receptor activator of NF-Kappa B ligand). RANKL was shown to augument the ability of dendritic cells to stimulate naïve T-cell proliferation. A soluble form of the protein consisting of only the extracellular domain is called TRANCE.
Synonyms	OPGL, RANK Ligand, RANKL, TRANCE, TNFSF11, ODF
Reference Data

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