Adipose Triglyceride Lipase (PNPLA2) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	ELISA: 1/32000. Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
Reactivity	Human, Mouse, Rat, Bovine, Equine, Goat, Hamster, Monkey
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide (C-NIIEVSKEARKR) from an internal region of Mouse PNPLA2.
Specificity	Recognizes Patatin-Like Phospholipase Domain Containing 2 (PNPLA2).
Formulation	Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Immunoaffinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	patatin like phospholipase domain containing 2
Database Link	Entrez Gene 57104 Human UniProt ID Q96AD5
Background	Adipose triglyceride lipase (ATGL) may function as a lipase and play a role in the adaptive response to a low energy state, such as fasting, by providing fatty acids to other tissues for oxidation. In addition, decreased expression of desnutrin in obesity models suggests its possible contribution to the pathophysiology of obesity. ATGL catalyzes the initial step in triglyceride hydrolysis in mammalian adipose tissue. ATGL contains a patatin domain common to plant acyl hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals
Synonyms	FP17548, Desnutrin, TTS2.2, IPLA2-zeta
Reference Data

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