Jagged1 (JAG1) (110-125) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA: 1/2500 - 1/10000. Immunocytochemistry. Immunofluorescence: 1/100 - 1/500. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 1/250 - 1/1000.
Reactivity	Human, Chimpanzee, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to aa 110-125 of Human Jagged-1 protein.
Specificity	Recognizes Human Jagged-1 (JAG1).
Formulation	PBS, pH 7.2 containing 0.01% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein A Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	jagged 1
Database Link	Entrez Gene 182 Human UniProt ID P78504
Background	Jagged-1 (JAG1) is a cell surface protein which is one of several ligands that activate Notch and related receptors. JAG1 functions in an embryologically important signaling pathway and has also been shown to play a role in hematopoiesis. JAG1 inhibits proliferation of cd34+ macrophage progenitor cells and a JAG1 gene abnormality may be an aggravating factor in extrahepatic biliary atresia. Activation of NOTCH1 signaling by JAG1 induces monocyte-derived dendritic cell maturation in vitro. JAG1 interaction with NOTCH1 on tumor cells dramatically induces proliferation and inhibition of apoptosis in vitro. Either haploinsufficiency for wild-type JAG1 and/or dominant negative effects produced by mutated JAG1 are responsible for the Alagille syndrome.
Synonyms	Jagged-1, hJ1, JAGL1
Note	Predicted Molecular Weight: 134 kDa.
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.