MARCKS pSer162 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF
Recommend Dilution	Immunofluorescence: 1/100~1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The antiserum was produced against synthesized phosphopeptide derived from human MARCKS around the phosphorylation site of serine 162 (K-K-Sp-F-K).
Specificity	Antibody AP09479PU detects endogenous levels of MARCKS only when phosphorylated at Serine 162.
Formulation	PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol. State: Aff - Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Immunoaffinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	myristoylated alanine rich protein kinase C substrate
Database Link	Entrez Gene 17118 MouseEntrez Gene 25603 RatEntrez Gene 4082 Human UniProt ID P29966
Background	MARCKS, (Myristoylated Alanine-Rich C Kinase Substrate), is a member of a family of calmodulin binding proteins and is a major substrate for phosphorylation by protein kinase C (PKC). The phosphorylation of Ser152/156 can be used as a measure of PKC activation. Phosphorylation of Ser152/156 modulates the binding of MARCKS to calmodulin.
Synonyms	Myristoylated alanine-rich C-kinase substrate, MACS, PRKCSL
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Fc gamma R-mediated phagocytosis

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