Desmoglein 4 (DSG4) (472-590) Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Cryostat Sections: 1/100. Incubation Time: 1 h at room temperature.
Reactivity	Human
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	Recombinant peptide corresponding to extracellular repeat domain E4 (aa 472–590) of Human Desmoglein 4.
Specificity	Antibody AP09539SU-N recognizes Desmoglein 4 present in the hair cortex, beginning at the height of the apex of the dermal papilla and cuticle (inner root sheath) from the upper differentiated part. Also positive staining is found in the stratum granulosum of epidermis.
Formulation	State: Serum State: Liquid Stabilized antiserum Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	desmoglein 4
Database Link	Entrez Gene 147409 Human UniProt ID Q86SJ6
Background	Desmoglein 4 (DSG4) is a component of intercellular desmosome junctions. DSG4 is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSG4 coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. The essential role of desmoglein 4 in skin was established by identifying mutations in families with inherited hypotrichosis, as well as in the lanceolate hair mouse. The human desmoglein 4 gene (DSG4) demonstrates that it is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 and DSG3. Defects in DSG4 are the cause of localized autosomal hypotrichosis (LAH). LAH is an autosomal recessive skin disorder. DSG4 is one of the target molecules recognized by autoantibodies in patients with pemphigus vulgaris. Pemphigus vulgaris is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion.
Synonyms	DSG4, CDHF13
Reference Data
Protein Families	Transmembrane

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