Cytokeratin 10 (KRT10) Guinea Pig Polyclonal Antibody
CAT#: AP09544SU-N
Cytokeratin 10 (KRT10) guinea pig polyclonal antibody, Serum
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CNY 5,610.00
货期*
5周
规格
Cited in 2 publications. |
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Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | Western Blot. Immunofluorescence Microscopy on Frozen Sections. Immunohistochemistry on Paraffin Sections (After Microwave treatment). Working Dilution: 1/100-1/200 for Immunohistochemistry. Incubation Time: 1h at RT. Positive Control: Human suprabasal keratinocytes of epidermis; squamous cell carcinoma. |
Reactivity | Human, Mouse, Rat |
Host | Guinea Pig |
Clonality | Polyclonal |
Immunogen | Synthetic peptide of Human Keratin K10 (formerly also designated Cytokeratin 10; C-GS VGE SSS KGP RY), coupled to KLH |
Specificity | MW 56,5000 (pI 5.3) intermediate filament polypeptide, keratin K10, detected by Immunohistochemistry in the suprabasal layers of Human epidermis (basal cells are negative). Useful for the recognition of keratinizing cells in squamous cell carcinoma of epidermis, lung, bladder, cervix, esophagus etc. Completely negative on non-stratified epithelia. |
Formulation | State: Serum State: Liquid Serum with 0.09% Sodium Azide and 0.5% BSA |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C. |
Gene Name | keratin 10 |
Database Link | |
Background | Cytokeratin 10 is a heterotetramer of two type I and two type II keratins. Cytokeratin 10 is generally associated with keratin 1. It is seen in all suprabasal cell layers including stratum corneum. A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560). Defects in cytokeratin 10 are a cause of epidermolytic hyperkeratosis (EHK), also known as bullous congenital ichthyosiform erythroderma (BCIE) or bullous erythroderma ichthyosiformis congenita of Brocq. EHK is an hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum. At birth, affected individuals usually present with redness, blisters and superficial erosions due to cytolysis. Within a few weeks, the erythroderma and blister formation diminish and hyperkeratoses develop. Transmission is autosomal dominant, but most cases are sporadic. Defects in cytokeratin 10 are also a cause of annular epidermolytic ichthyosis (AEI), also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI resembles clinical and histologic features of both epidermolytic hyperkeratosis and ichthyosis bullosa of Siemens. |
Synonyms | Cytokeratin-10, CK10, CK-10, Keratin-10, KRT10, KPP, K10 |
Reference Data |
Citations (2)
The use of this Antibodies has been cited in the following citations: |
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Mutations in ASPRV1 Cause Dominantly Inherited Ichthyosis
,Boyden, LM;Zhou, J;Hu, R;Zaki, T;Loring, E;Scott, J;Traupe, H;Paller, AS;Lifton, RP;Choate, KA;,
Am. J. Hum. Genet.
,PubMed ID 32516568
[KRT10]
|
Recessive Mutations in AP1B1 Cause Ichthyosis, Deafness, and Photophobia
,Boyden, LM;Atzmony, L;Hamilton, C;Zhou, J;Lim, YH;Hu, R;Pappas, J;Rabin, R;Ekstien, J;Hirsch, Y;Prendiville, J;Lifton, RP;Ferguson, S;Choate, KA;,
Am. J. Hum. Genet.
,PubMed ID 31630788
[KRT10]
|
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