Cytokeratin 10 (KRT10) Guinea Pig Polyclonal Antibody

CAT#: AP09544SU-N

Cytokeratin 10 (KRT10) guinea pig polyclonal antibody, Serum



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CNY 5,610.00


货期*
5周

规格
    • 100 ul

Cited in 2 publications.

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Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution Western Blot.
Immunofluorescence Microscopy on Frozen Sections.
Immunohistochemistry on Paraffin Sections
(After Microwave treatment).
Working Dilution: 1/100-1/200 for Immunohistochemistry.
Incubation Time: 1h at RT.
Positive Control: Human suprabasal keratinocytes of epidermis; squamous cell carcinoma.
Reactivity Human, Mouse, Rat
Host Guinea Pig
Clonality Polyclonal
Immunogen Synthetic peptide of Human Keratin K10 (formerly also designated Cytokeratin 10; C-GS VGE SSS KGP RY), coupled to KLH
Specificity MW 56,5000 (pI 5.3) intermediate filament polypeptide, keratin K10, detected by Immunohistochemistry in the suprabasal layers of Human epidermis (basal cells are negative).
Useful for the recognition of keratinizing cells in squamous cell carcinoma of epidermis, lung, bladder, cervix, esophagus etc.
Completely negative on non-stratified epithelia.
Formulation State: Serum
State: Liquid Serum with 0.09% Sodium Azide and 0.5% BSA
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C.
Gene Name keratin 10
Background Cytokeratin 10 is a heterotetramer of two type I and two type II keratins. Cytokeratin 10 is generally associated with keratin 1. It is seen in all suprabasal cell layers including stratum corneum. A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560). Defects in cytokeratin 10 are a cause of epidermolytic hyperkeratosis (EHK), also known as bullous congenital ichthyosiform erythroderma (BCIE) or bullous erythroderma ichthyosiformis congenita of Brocq. EHK is an hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum. At birth, affected individuals usually present with redness, blisters and superficial erosions due to cytolysis. Within a few weeks, the erythroderma and blister formation diminish and hyperkeratoses develop. Transmission is autosomal dominant, but most cases are sporadic. Defects in cytokeratin 10 are also a cause of annular epidermolytic ichthyosis (AEI), also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI resembles clinical and histologic features of both epidermolytic hyperkeratosis and ichthyosis bullosa of Siemens.
Synonyms Cytokeratin-10, CK10, CK-10, Keratin-10, KRT10, KPP, K10
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (2)

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