Slc6a11 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/200-1/5000.  Immunohistochemistry: 1/50-1/500.
Reactivity	Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A 15 residue synthetic peptide derived from C-terminal domain of Rat GAT-3
Specificity	This antibody reacts with 74 kDa GAT-3 from Rat, Mouse and Human central nervous system.
Formulation	State: Serum State: Lyophilized powder
Reconstitution Method	Restore in distilled water.
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	solute carrier family 6 member 11
Database Link	Entrez Gene 79213 Rat UniProt ID P31647
Background	Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-3 has been found to be localized to astrocytes within the cerebral cortex indicating that this transporter mediates GABA uptake into glial cells (Minelli et al., 1996).
Synonyms	GABT3, GAT-3
Reference Data

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