IKK beta (IKBKB) pTyr199 Rabbit Polyclonal Antibody

CAT#: AP12624PU-N

IKK beta (IKBKB) pTyr199 rabbit polyclonal antibody, Aff - Purified



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CNY 6,446.00


货期*
5周

规格
    • 400 ul

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Specifications

Product Data
Applications WB
Recommend Dilution ELISA: 1/1,000.
Western Blot: 1/100-1/500.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y199 of human IKKb.
Specificity This antibody detects IKKb pTyr199.
Predicted to cross react with Mouse (100% Antigen Homology).
Formulation PBS with 0.09% (W/V) Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Protein G Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Background NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the inhibitory I-kappa-B proteins by kinases (IKKa or IKKb) leads to the dissociation of the inhibitor/NF-kappa-B complex and marks the inhibitors for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs.
Synonyms I-kappa-B-kinase beta, IKK-beta, IKK-B, I-kappa-B kinase 2, IKK2, NFKBIKB
Note Molecular weight: 86564 Da
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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