TGIF (TGIF1) (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA 1:1,000. Western blot 1:50 - 1:100.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human TGIF1.
Specificity	This antibody detects TGIF at center.
Formulation	Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. State: Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	PBS with 0.09% (W/V) sodium azide
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	TGFB induced factor homeobox 1
Database Link	Entrez Gene 7050 Human UniProt ID Q15583
Background	TGIF1 is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.
Synonyms	TGIF
Note	Molecular weight: 43044 Da
Reference Data

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