Pumilio 1 (PUM1) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Peptide ELISA: 1/1,000. Western blotting: 11,000. Immunohistochemistry: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 133-162 amino acids from the N-terminal region of human PUM2.
Specificity	This antibody reacts to Pumilio 1 (PUM1).
Formulation	PBS with 0.09% (W/V) sodium azide State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	pumilio RNA binding family member 1
Database Link	Entrez Gene 9698 Human UniProt ID Q14671
Background	PUM1 is a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. This protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of this protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation.
Synonyms	Pumilio homolog 1, HsPUM, Pumilio-1, PUMH1, KIAA0099
Reference Data

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